Betis stun rivals Real Betis stunned city rivals Sevilla with a 2-0 win despite being outplayed for much of the first leg.
Lyon thump Plzen Lyon took a huge step towards the quarter-finals of the Europa League as they claimed a 4-1 win over Plzen.
Spurs left with mountain to climb Tottenham Hotspur's Europa League hopes were left hanging by a thread as Benfica stunned White Hart Lane to win 3-1.
Valencia cruise past Ludogrets Valencia virtually assured themselves of a quarter-final place in the Europa League after a 3-0 win at Ludogrets.
Martinez hands Porto the advantage Jackson Martinez scored the only goal in the 57th minute as Porto claimed a 1-0 first-leg advantage over Napoli.
Late flurry sees Benfica through Three late goals saw Benfica ease into the last 16 of the Europa League as they completed a 4-0 aggregate win over PAOK.
Fiorentina set up Juve clash Fiorentina set up an all-Italian clash with Juventus in the Europa League last 16 after a 4-2 aggregate win over Esbjerg.
Juve thrash Trabzonspor Juventus comfortably crushed Trabzonspor 2-0 in Turkey and will play Fiorentina in the next Europa League round.
Spurs Turn Tables On Dnipro Emmanuel Adebayor scored twice as Spurs came from a goal down to beat Dnipro 3-1 and book a meeting with Benfica in the last-16.
Swans bow out in Naples Swansea's Europa League adventure came to an end in Italy as they lost 3-1 to Napoli on Thursday.
Porto progress after fightback Nabil Ghilas struck a dramatic 86th-minute equaliser to send Porto through to the last 16 of the Europa League.
Ludogorets seal famous win Lazio had taken the lead after 18 seconds, but defensive errors saw them crash out 4-3 on aggregate to Ludogorets.
Salzburg saunter into last-16 Salzburg waltzed into the last-16 of the Europa League with a comfortable 6-1 aggregate success against Ajax.
Sevilla tee up derby clash Sevilla set up a mouthwatering showdown with arch-rivals Real Betis in the last 16 of the Europa League.
Frankfurt fight back to stun Porto Eintracht Frankfurt struck twice in quick succession after the break to stun Porto and seal a hard-earned 2-2 draw.